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Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

  • Jingjing Wu,
  • Hui Li and
  • Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123

Graphical Abstract
  • building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile. Keywords: difluoromethyl functionality; gem-difluoromethylene-containing acid; pseudopeptides; reductive
  • continuation of our interest in the synthesis of diverse difluoromethyl-containing pseudopeptides, we herein report a novel and efficient synthesis of difluoromethyl-containing pseudopeptides through Ugi reaction, with gem-difluoromethylene-containing acid as a key component, followed by reductive cleavage of
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Published 08 Aug 2011
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