Beilstein J. Org. Chem.2011,7, 1070–1074, doi:10.3762/bjoc.7.123
building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile.
Keywords: difluoromethyl functionality; gem-difluoromethylene-containingacid; pseudopeptides; reductive
continuation of our interest in the synthesis of diverse difluoromethyl-containing pseudopeptides, we herein report a novel and efficient synthesis of difluoromethyl-containing pseudopeptides through Ugi reaction, with gem-difluoromethylene-containingacid as a key component, followed by reductive cleavage of
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Graphical Abstract
Figure 1:
Two examples of bioactive pseudopeptides bearing a CF2H group.